The evolution of adult comics has also led to a greater diversity of content, with more creators exploring themes of sex, relationships, and identity. The stigma surrounding adult comics has decreased, with many mainstream artists and writers exploring adult themes in their work.

The impact of "2 Hot Blondes 12" on the adult comic scene cannot be overstated. The title has become a benchmark for adult comics, pushing the boundaries of what is considered acceptable in terms of content and storytelling. The comic's popularity has also helped to establish John Persons as a leading figure in the adult comic industry, with a loyal following among fans.

The future of adult comics will likely involve even greater diversity of content, with more creators exploring themes of sex, relationships, and identity. As the stigma surrounding adult comics continues to decrease, we can expect to see more mainstream artists and writers exploring adult themes in their work.