This betrayal is worse than any medical mystery. House watches his best friend fall for a female version of himself (Amber is manipulative, ambitious, and cold). The resulting psychological warfare is Shakespearean. House sabotages Wilson’s relationship, breaks into his apartment, and ultimately forces Wilson to choose. Wilson chooses Amber.
Best Episode: "Wilson’s Heart" (Season 4, Episode 16) Worst Episode: "Whatever It Takes" (Season 4, Episode 6) Should you rewatch it? Absolutely. Bring tissues for the finale. Were you a fan of the Season 4 Fellowship arc? Do you think "Cutthroat Bitch" deserved a better fate? Let us know in the comments below. House MD - Season 4
House recovers the memory. The passenger was Amber. She was on the bus, suffering from a lethal flu-like syndrome that causes rhabdomyolysis and kidney failure. House must now save the life of the woman he hates—for Wilson’s sake. This betrayal is worse than any medical mystery
This season proves that Gregory House is not a hero. He is a tragic figure. He destroyed his relationship with Cuddy (Season 5), his friendship with Wilson (Season 4), and his team (Season 3). Season 4 is the season where the show stops asking, "Will House solve the case?" and starts asking, "Will House destroy everyone who loves him?" Absolutely