A Windows/Mac PC to create the USB, a USB drive (8GB+), and your target x64 machine.

A: No. This is the biggest limitation. For Android apps on x64 hardware, use FydeOS or Brunch.

But here is the first hard truth you need to understand:

If you want a professional, stable, and updated version of Chrome OS on your x64 PC, stop looking for an ISO. Use via the Chromebook Recovery Utility. If you need Android apps, use FydeOS (which does offer a real ISO). If you are a tinkerer, use the Brunch framework .